Preparation of chiral isoxazole carbinols via catalytic asymmetric Corey-Bakshi-Shibata reduction.
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چکیده
منابع مشابه
Enantioselective synthesis of 2,2-disubstituted terminal epoxides via catalytic asymmetric Corey-Chaykovsky epoxidation of ketones.
Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li(3)-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (97%-91% ee) and yield ( > 99%-88%) f...
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The enantioselective addition of alcohols to imine electrophiles has been shown to proceed in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction allows for the formation of the respective chiral N,O-aminals in excellent yield and enantioselectivity. A total of 11 different alcohols and 11 different imines were successfully used as a clear demonstration of the ...
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A chiral indium complex has been discovered to effect high enantioselectivities in the addition of allyltributyl stannanes to aldehydes. The allylation of a variety of aromatic, alpha,beta-unsaturated and aliphatic aldehydes resulted in good yields and high enantioselectivities (90-96% ee).
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Chiral monophosphines (MOPs), whose chirality is due to biaryl axial chirality, are prepared from enantiometrically pure 2,2%-dihydroxy-1,1%-binaphthyl and 3,3%-dihydroxy-4,4%-biphenanthryl. The representatives are 2-(diphenylphosphino)-2%-methoxy1,1%-binaphthyl (MeO–MOP and 3-(diphenylphosphino)-3%-methoxy-4,4%-biphenanthryl (MOP–phen). The palladium complexes coordinated with the MOP ligands ...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2010
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0011.809